Statistica Sinica 9(1999), 1011-1027
STATISTICAL EVALUATIONS OF DISSOLUTION SIMILARITY
Mi-chia Ma
,
Ru-pyng Lin
and Jen-pei Liu
National Cheng-kung University and
National Health Research Institutes
Abstract:
Statistical properties of several criteria
for assessment of similarity between two dissolution profiles
are investigated.
These include the similarity factor 
,
and metrics based on the mean squared distance and the mean absolute
difference. The probability density function
of
and its first two moments are derived under the assumption of
multivariate normality, with special attention to
compound symmetry covariance structure.
The intractable nature of the distribution of
is demonstrated. Empirical results from a
large simulation study are also presented.
Advantages and drawbacks of
proceduces based on the mean absolute
difference and mean squared distance are discussed.
Key words and phrases:
Dissolution, similarity factor.