Editor's Melange Highlights -- A master of minds ........................................ Jianqing Fan 399 Editorial -- A rigorous statistician and passionate educator .............Jiahua Chen 401 Memorial Articles to Xiru Chen On constrained M-estimation and its recursive analog in multivariate linear regression models............................................Zhidong Bai, Xiru Chen and Yuehua Wu 405 Large sample covariance matrices without independence structures in columns............ .............................................................Zhidong Bai and Wang Zhou 425 Inference for normal mixtures in mean and variance ................................... ............................................Jiahua Chen, Xianming Tan and Runchu Zhang 443 General Estimating monotone, unimodal and U--shaped failure rates using asymptotic pivots..... ................................................................ Moulinath Banerjee 467 Factorial designs with multiple levels of randomization ........................... .....Derek Bingham, Randy Sitter, Elizabeth Kelly, Leslie Moore and J. Davaid Olivas 493 Design-adaptive minimax local linear regression for longitudinal/clustered data.... ............................................ Kani Chen, Jianqing Fan and Zhezhen Jin 515 Information identities and testing hypotheses: Power analysis for contingency tables. ................ Philip E. Cheng, Michelle Liou, John A. D. Aston and Arthur C. Tsai 535 Confidence intervals for the long memory parameter based on wavelets and resampling ............Pier Luigi Conti, Livia De Giovanni, Stilian A. Stoev and Murad S. Taqqu 559 Classification efficiencies for robust linear discriminant analysis ................ ................................ Christophe Croux, Peter Filzmoser and Kristel Joossens 581 Tests for independence in nonparametric regression ................................. ......................................... John H. J. Einmahl and Ingrid Van Keilegom 601 Minimum distance inference in unilateral autoregressive lattice processes........... ........................................................Marc G. Genton and Hira L. Koul 617 A circular-circular regression model ..... Shogo Kato, Kunio Shimizu and Grace S. Shieh 633 Testing for threshold moving average with conditional heteroscedasticity............ ........................................................ Guodong Li and Wai Keung Li 647 Spatial bootstrap with increasing observations in a fixed domain ................... ...........................................................J. M. Loh and M. L. Stein 667 Most robust BIBDs ......................................J. P. Morgan and Valentin Parvu 689 A nonparametric empirical Bayes approach to joint modeling of multiple sources of genomic data...........................Wei Pan, Keyong S. Jeong, Yang Xie and Arkady Khodursky 709 Between-and within-cluster covariate effects and model misspecification in the analysis of clustered data........................Lei Shen, Jun Shao, Soomin Park and Mari Palta 731 Asymptotically efficient product-limit estimators with censoring indicators missing at random..........................................................Qihua Wang and Kai W. Ng 749 [online supplement] Moderate deviations for stationary processes ...............Wei Biao Wu and Zhibiao Zhao 769 Detecting differentially expressed genes using calibrated Bayes factors................ ....................................................Fang Yu, Ming-Hui Chen and Lynn Kuo 7832008 Statistica Sinica ISSN 1017-0405